John Proudfoot, Ph. D.

30 years of experience in the pharmaceutical industry.
Leadership roles medicinal chemistry, lead identification and new concept development.
Track record of productive collaboration across disciplines to achieve project milestones.

Colleagues know me as an innovative, creative scientist who can be trusted to work collaboratively in developing practical approaches to lead generation for novel targets or concepts. I have deep experience in all aspects of medicinal chemistry particularly around lead identification by high throughput and fragment-based screening, rational design, and structure-property optimization.

Knime, Datawarrior, ICM-Chemist, Cytoscape as supporting tools.

Currently
Consulting for early stage Biotechnology companies.

2017 - 2023
Consulted for Kintai, Senda, Kaerus, Janpix, Kayothera among others.

To December 2016:
Director, Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Ridgefield.
Led a group responsible for early milestone delivery in the NCE portfolio
Delivered tool and lead compounds across many target types.
Key role in the implementation of fragment-based lead identification at BI in Ridgefield.

Further back:
Co-inventor of nevirapine, the first non-nucleoside HIV-1 reverse transcriptase inhibitor approved for the treatment of AIDS.

Expertise
Medicinal Chemistry and Drug Design
All aspects of lead identification and progression
    Analysis of hitsets, frequent hitters, cluster analysis
    Evolution of hits from fragment based screening
    Analog-based drug design
    Structure based design
Data processing, visualization and analysis
Patent analysis and generation of novel intellectual property

Additionally:
> 50 peer reviewed publications, 33 issued US patents, numerous scientific presentations.
Coinventor on 20 patent applications 2017 - 2023
Section editor “Successful Drug Discovery” Fischer, 2017.
Section editor “The Practice of Medicinal Chemistry” 3rd edition, Wermuth, 2008.
F1000 Faculty of Biology contributor (2007-2012)
Team member Pistoia Alliance project on Controlled Substances (2013-4)

American Chemical Society, Medicinal Chemistry Division.
American Association for the Advancement of Science
IUPAC, subcommittee on Medicinal Chemistry and Drug Development
New York Academy of Sciences