In an earlier post looking at the origins of new drugs approved in 2018, it was clear that the vast majority originated in the US and a timeline view of invention location for marketed drugs shows that this reflects a trend running since the early 1990’s.
The dataset is a consolidation of information from many sources accumulated over many years including:
Drug Prototypes and their exploitation, Sneader.
Drugs Available Abroad, A Guide to Therapeutic Drugs, Schlesser.
Annual reports in Medicinal Chemistry